A new group of scientists has discovered a new tea filter which can treat smoking addiction and have observed the molecular system behind the smoking cessation effects. A famous professor Zhao Baolu and his researchers group from the State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences discovered theanine active ingredients in the tea filter that prevents nicotine addiction. Their new research was entitled “The cessation and detoxification effect of tea filters on cigarette smoke”.
As it is known tobacco smoking has been linked to many life threatening diseases like heart disease, cancer and also chronic obstructive pulmonary disease.
Every year scientists and clinics try many methods for smoking cessation. In spite of all efforts, at present available smoking cessation methods produce only some success rates with frequent relapse. Due to the addictive nature of nicotine, quitting smoking remains the most difficult task. And so, the need for developing new smoking cessation strategies with better effectiveness and fewer side effects is urgently.
The new human tests using a newly developed tea filter were conducted at the Addiction Branch of Beijing Military Region General Hospital. In the new study were enrolled more than 100 male smokers. The results from the first test showed that the participants’ average daily cigarette consumption decreased by approximately 43 percent and 56.5 percent after using the tea filters for 1 and 2 months, respectively.
And the results from the second test showed that the participants’ average daily cigarette consumption decreased by about 48 percent, 83 percent and 91 percent after using the tea filters for 1, 2 and 3 months.
So, the average daily cigarettes consumed by the participants decreased from approximately 24.5 per day to about 3 per day at the end of 3 months of treatment. In addition, most participants showed that saliva and their smoking-related symptoms were reduced compared with the control group. Physical examinations of the participants did not reveal any apparent side effects.
The mechanism of action (MOA) studies recommended that theanine in the filter exerted an inhibitory effect similar to the nicotine acetylcholine receptor (nAChR) inhibitor. In addition, theanine could meaningly inhibit the nicotine-induced increased expression of nAChR and the increase of the neurotransmitter dopamine (DA) released in mouse brains.
But the toxicological studies showed that the tea filters could reduce even the carcinogenic materials such as tar, free radicals, nitrosamine, benzoapyrene, benzoaanthracene, chrysene and total polycyclic aromatic hydrocarbons (PAHs) generated in cigarette smoking.